Its use was limited due to its narrow spectrum of

One prospective controlled study estimated the risk of arthropathy as 9.3 (OR 95% CI 1.2 to 195). Its use was limited due to its narrow spectrum of antibacterial activity Replica Hermes Handbags, low serum levels and toxicity issues.1 Fluorination of the quinolone nucleus at position 6 resulted in introduction of second, third and fourth generations of fluoroquinolones, with ciprofloxacin in 1987 as a second generation fluoroquinolone.2 Ciprofloxacin is a broad spectrum, bactericidal antibiotic which acts by binding two of the four topoisomerases of bacteria.3The use of ciprofloxacin and fluoroquinolones as a group in paediatric patients has been limited due to arthropathy noticed in weight bearing joints of juvenile animals. Cartilage damage caused by quinolones (nalidixic, oxolinic and pipemidic acids) was first reported in juvenile animals (beagle dogs 4 12 months of age).4 The arthropathy caused by quinolones has also been demonstrated in other animal species such as mice,5 dogs Replica Hermes,6 rats7 and rabbits,8 and in in vitro animal culture9 and in vitro human cell culture.10What is already known on this topic Ciprofloxacin is a broad spectrum, bactericidal antibiotic with good tissue penetration.

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